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The Most Uplifting Cannabis Hybrid Strains of 2021

Written by Ashley Torres

Cannabis is a pretty diverse plant, and thanks to various breeding methods, weed experts create new strains that deliver different sets of effects to the user’s body and mind. Some can help you relax and unwind, while others can uplift you and put you in a state of euphoria where you can experience extreme amplification of joy, pleasure, and excitement.

If you are searching for the best energetic strain, keep reading as some of the top choices are listed below.

Uplifting and Euphoric Effects From Weed

Cannabis indica and cannabis sativa are two main cannabis types. The first one has relaxation properties, and the second one delivers mood-uplifting and energizing effects. Sativa options can help reduce stress, anxiety, and fear. They can replace these negative feelings with opposite ones, such as joy, happiness, and excitement.

There are hybrid strains as well – the combination of sativa and indica and these tend to deliver both types of effects. If the strain is indica-dominant, indica effects will lead the way, and if the strain is sativa-dominant, users can expect an uplifting high.

Apple Sherbet

Apple Sherbet is a hybrid strain with sativa dominance that provides the users with more energy and focus. If you’re looking for upliftment and euphoria, this stain could be a perfect choice. It has a candy-like, super delicious taste, which only boosts the overall experience. It has a high THC content. Newbies and those who have not yet tried the options with such high THC levels are advised to begin with a smaller dosage.

Pop Tarts

With a creamy and sweet flavor, this sativa-dominant strain offers a delicious taste and extremely enjoyable high effects. Many users will agree that Pop-Tarts is one of the best options for creativity, so those looking for a boost in the creativity department can’t go wrong with this one. In addition, it will lift you up, and you will feel happy vibes all over the place. It has average levels of THC, and it is excellent for mornings and afternoons.

Orange Sunset

Orange Sunset is the indica-dominant strain with the taste and aroma of lime candy, creamy citrus soda, orange, and pine. It’s a hybrid of OZ Kush and Orange Banana. The strain with high THC levels delivers the combination of effects that many users consider perfect – the calm mind, complete relaxation of the body with uplifting energy, and euphoria.    

Gorilla Glue

Gorilla Glue strain, also known as Original Glue, Gorilla Glue #4, and GG4, is a hybrid with sativa dominance with earthy and woody notes. It is best known for its high THC levels. The best time to use it is during the night because Gorilla Glue delivers deep relaxation in combination with feelings of euphoria. The strain is great for reducing anxiety, stress, and depression.


Squirt is a hybrid of Blueberry Muffin and Tangie. The combination of two provides a lovely aroma that smells exactly like a caffeine-free soft drink called Squirt. With the tart grapefruit flavor, this strain with sativa-dominance could be one of the most energetic weed strains – it leaves the users uplifted, happy, and full of energy.

Rocket Fuel

Rocket Fuel is one of the super rare strains of indica-dominance (70% indica and 30 % sativa). It is a cross between Face Off OG Bx1 and Jet Fuel OG with a spicy and earthy aroma with diesel notes. It features high THC content. When it comes to the effects, Rocket Fuel calms the body but leaves you completely euphoric.

Blueberry OG

Blueberry OG effects are the main reason why so many users love the strain so much. It has a reputation of helping smokers calm their minds, reduce anxiety and stress. It is an indica-dominant strain with a blueberry-rich taste mixed with earthy, sour, diesel, and piney notes. The strain is rich in THC.


Another hybrid cannabis strain is the mixture of Gelato and Shebert. It is a bud of sativa-dominance (70 % sativa and 30 % indica), with normal THC levels. It comes with fruity flavors followed by tropical citrus and a bit of sourness. Sherblato strain is delicious, but that’s not the only reason why many users love it so much. The strain brings relaxation and euphoria in a mix. Some smokers tend to socialize more while others get a creativity boost.

Strawberry OG

Strawberry OG should not be confused with OG Strawberry, a strain with a similar name. The Strawberry OG is a cross between SFV OG and Bruce Banner with a higher THC content that varies between 15 and 25 %. The aroma and taste are all about the strawberries. The effects the strain delivers are creative inspiration, relaxation, and euphoria.

Larry Bird (Larry Bird Kush)

Larry Bird is a bud, also known as The great white hope and Larry Bird Kush. The strain is 50 % sativa and 50 % indica that features mint, lemon, and pine flavors, and it’s a cross of Sunset Sherbet and Thin Mint Girl Scout cookies. It is rich in THC. The strain brings relaxation and upliftment with lots of happy vibes. You can count on the burst of energy and creativity, and you may be extra productive, at least for a while.


Sometimes, you feel creative, energized, fulfilled, and everything seems great. But sometimes, you need something to push you forward, especially when your creative juices aren’t flowing or when you feel anxious, exhausted, and stressed.

Many hybrid strains of cannabis deliver effects such as the burst of energy, extra focus and creativity, happiness, joy, euphoria, and upliftment. Some options offer the complete relaxation of the body, so you can lie on the couch feeling calmness in body and happiness in mind at the same time.

Many people consume weed when they seek extra creativity and energy. With that said, remember that a carefully selected hybrid strain can be your sidekick in times when you’re not on your highest. Depending on the strain, you can get those ideas flowing again, be extra focused, or feel energized, euphoric, happy, and full of life.